IVL

Across TCGA patient cohorts, IVL mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IVL-associated genes across cancer lineages are JNK2, TFRC, and ASNS. Each is linked with IVL in more than 2 cancer types. Because this analysis shows association rather than direction, both IVL-to-partner and partner-to-IVL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by IVL-low versus IVL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IVL→partner) and Y-score (partner→IVL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.312	+2.232	<.001	.005	3	3
UCEC	TFRC →	+0.595	+3.169	.005	.018	3	3
UCEC	ASNS →	+0.335	+2.999	.021	.035	3	3
SKCM	TIGAR →	+0.130	+2.182	.036	.033	3	2
UCEC	Bcl-2 →	-0.320	-2.302	.021	.034	3	2
SKCM	LKB1 →	+0.112	+2.359	.043	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

JNK2 by IVL expression — UCEC

Explore this box plot interactively →