IVL

Across TCGA cell cohorts, IVL RNA expression is significantly associated with the go_rna of many other GO terms, with 2,579 significant associations in total. URINARY_TRACT shows the largest number of these associations.

The most reproducible IVL-associated GO terms across cancer lineages are Small GTPase-mediated signal transduction, Regulation of apoptotic signaling pathway, and Positive regulation of ATP biosynthetic process. Each is linked with IVL in more than 8 cancer types. Because this analysis shows association rather than direction, both IVL-to-partner and partner-to-IVL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Small GTPase-mediated signal transduction grouped by IVL-low versus IVL-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IVL→partner) and Y-score (partner→IVL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Small GTPase-mediated signal transduction →	+0.050	+3.421	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Regulation of apoptotic signaling pathway →	+0.064	+2.603	<.001	.001	3	9
UPPER_AERODIGESTIVE_TRACT	Positive regulation of ATP biosynthetic process →	+0.141	+2.491	.005	.008	3	8
URINARY_TRACT	Regulation of hippocampal neuron apoptotic process →	+1.278	+2.957	<.001	<.001	3	8
URINARY_TRACT	Negative regulation of hippocampal neuron apoptotic process →	+1.195	+2.957	<.001	<.001	3	8
URINARY_TRACT	Protein localization to cell-cell junction →	+0.155	+2.956	<.001	.002	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,579 associations by consensus.

Small GTPase-mediated signal transduction by IVL expression — URINARY_TRACT

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