IVD

Across TCGA pan-cancer cohorts, IVD mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated IVD data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher IVD mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated IVD expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

CCRCC, LSCC, and GBM are the cancer types where IVD mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	All	1.000	0.479	.031	14	view →
LSCC	DFS	Tertile	All	0.572	1.000	.006	8	view →
GBM	DFS	Quartile	All	0.580	0.298	.019	4	view →
UCEC	DFS	Median	II,III,IV	0.538	0.862	.048	4	view →
PDAC	OS	Quartile	All	1.000	0.763	.010	4	view →
LUAD	DFS	Median	III,IV	0.518	0.959	.029	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

IVD–CCRCC (DFS)

Open the CCRCC breakdown →