Across TCGA patient cohorts, ITSN2 mutation is significantly associated with the RNA expression of many other genes, with 4,949 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITSN2-associated genes across cancer lineages are GNPAT, ACOT9, and NDC80. Each is linked with ITSN2 in more than 3 cancer types. Because this analysis shows association rather than direction, both ITSN2-to-partner and partner-to-ITSN2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITSN2→partner) and Y-score (partner→ITSN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	GNPAT →	+0.471	+1.867	.002	.005	3	4
UCEC	ACOT9 →	+0.304	+2.169	.002	<.001	3	4
UCEC	NDC80 →	+0.473	+2.008	.005	<.001	3	4
UCEC	RNA5SP411 →	+0.642	+1.393	<.001	.001	3	3
SKCM	SEC22A →	+0.323	+2.267	.008	.001	3	3
UCEC	UFD1 →	+0.406	+1.979	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,949 associations by consensus.

Exploration

ITSN2 survival (RNA) · tumor vs normal (RNA) · all ITSN2 data types