Across TCGA patient cohorts, ITSN2 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITSN2-associated genes across cancer lineages are STAT3_pY705, Cyclin-B1, and ERK2. Each is linked with ITSN2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ITSN2-to-partner and partner-to-ITSN2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITSN2→partner) and Y-score (partner→ITSN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	STAT3_pY705 →	-0.310	-2.999	.014	.035	3	3
UCEC	Cyclin-B1 →	+0.601	+3.169	<.001	<.001	3	3
BLCA	ERK2 →	+0.225	+3.012	.005	.018	3	2
UCEC	FoxM1 →	+0.176	+1.398	.017	.004	3	2
UCEC	JNK_pT183_Y185 →	-0.112	-1.874	.019	.002	3	2
UCEC	Notch1 →	+0.116	+1.672	.003	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

Exploration

ITSN2 survival (RNA) · tumor vs normal (RNA) · all ITSN2 data types