Across TCGA patient cohorts, ITSN1 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITSN1-associated genes across cancer lineages are MIG-6, eIF4E, and NF-kB-p65_pS536. Each is linked with ITSN1 in more than 3 cancer types. Because this analysis shows association rather than direction, both ITSN1-to-partner and partner-to-ITSN1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITSN1→partner) and Y-score (partner→ITSN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIG-6 →	+0.088	+2.597	.023	.005	3	4
SKCM	eIF4E →	+0.238	+2.222	.001	.010	3	4
BLCA	NF-kB-p65_pS536 →	-0.492	-2.999	.001	.035	3	3
BLCA	PKC-a_pS657 →	-0.471	-3.321	.002	.010	3	3
COAD	FASN →	+0.361	+1.593	.018	.043	3	3
UCEC	ATM →	-0.639	-1.887	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

Exploration

ITSN1 survival (RNA) · tumor vs normal (RNA) · all ITSN1 data types