Across TCGA patient cohorts, ITPRIPL2 mutation is significantly associated with the RNA expression of many other genes, with 6,197 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITPRIPL2-associated genes across cancer lineages are TWF1, CDC42SE2, and PGGT1B. Each is linked with ITPRIPL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ITPRIPL2-to-partner and partner-to-ITPRIPL2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITPRIPL2→partner) and Y-score (partner→ITPRIPL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TWF1 →	+0.622	+1.999	<.001	<.001	3	3
UCEC	CDC42SE2 →	+0.498	+1.754	<.001	.001	3	3
UCEC	PGGT1B →	+0.538	+2.021	<.001	<.001	3	3
UCEC	PRDX3 →	+0.639	+1.999	<.001	<.001	3	3
UCEC	GHITM →	+0.684	+1.999	<.001	<.001	3	3
UCEC	API5 →	+0.750	+2.595	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,197 associations by consensus.

Exploration

ITPRIPL2 survival (RNA) · tumor vs normal (RNA) · all ITPRIPL2 data types