Across TCGA cell cohorts, ITPRIPL2 mutation is significantly associated with the drug of many other genes, with 74 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ITPRIPL2-associated genes across cancer lineages are PAK_5339, GSK1904529A, and Niraparib. Each is linked with ITPRIPL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ITPRIPL2-to-partner and partner-to-ITPRIPL2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITPRIPL2→partner) and Y-score (partner→ITPRIPL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PAK_5339 →	+0.377	+2.900	.006	.015	3	2
LARGE_INTESTINE	GSK1904529A →	+0.607	+2.922	<.001	.011	3	1
LARGE_INTESTINE	Niraparib →	+0.422	+2.678	.011	.037	3	1
LARGE_INTESTINE	AZD5438 →	+0.517	+3.000	.026	.017	3	1
LARGE_INTESTINE	LCL161 →	+0.306	+2.868	.048	.022	3	1
LARGE_INTESTINE	Leflunomide →	+0.273	+2.991	.024	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 74 associations by consensus.

Exploration

ITPRIPL2 survival (RNA) · tumor vs normal (RNA) · all ITPRIPL2 data types