Across TCGA cell cohorts, ITPRIPL1 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ITPRIPL1-associated genes across cancer lineages are OR10K1, GHRH, and PATE1. Each is linked with ITPRIPL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ITPRIPL1-to-partner and partner-to-ITPRIPL1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITPRIPL1→partner) and Y-score (partner→ITPRIPL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR10K1 →	+0.002	+3.700	<.001	.009	3	2
OESOPHAGUS	GHRH →	+0.060	+4.906	<.001	.006	3	1
BLOOD_Leukemia	PATE1 →	+0.024	+3.234	.003	.008	3	1
BLOOD_Leukemia	CD8B →	+1.592	+3.667	.001	.006	3	1
BLOOD_Leukemia	SFT2D3 →	+0.358	+3.450	.004	.004	3	1
BLOOD_Leukemia	LRRC10 →	+0.191	+3.544	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Exploration

ITPRIPL1 survival (RNA) · tumor vs normal (RNA) · all ITPRIPL1 data types