ITPR3

Across TCGA pan-cancer cohorts, ITPR3 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated ITPR3 data layer compared with 25 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher ITPR3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ITPR3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

CCRCC, HNSC, and PDAC are the cancer types where ITPR3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	II,III,IV	0.235	0.887	.005	18	view →
HNSC	DFS	Median	II,III,IV	0.988	0.904	.008	11	view →
PDAC	OS	Median	III,IV	0.594	0.283	.004	10	view →
UCEC	DFS	Quartile	III,IV	1.000	0.412	.040	4	view →
GBM	OS	Median	All	0.279	0.446	.019	4	view →
LSCC	DFS	Median	All	0.627	0.916	.035	1	view →
LUAD	DFS	Tertile	All	0.922	0.526	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

ITPR3–CCRCC (DFS)

Open the CCRCC breakdown →