ITPR3

Across TCGA patient cohorts, ITPR3 protein abundance is significantly associated with the RNA expression of many other genes, with 11,250 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ITPR3-associated genes across cancer lineages are ERGIC1, MAPK13, and ABCD2. Each is linked with ITPR3 in more than 4 cancer types. Because this analysis shows association rather than direction, both ITPR3-to-partner and partner-to-ITPR3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ITPR3 versus ERGIC1 in BRCA, with a Pearson correlation of 0.29.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITPR3→partner) and Y-score (partner→ITPR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ERGIC1 →	+0.754	+0.568	<.001	<.001	3	5
GBM	MAPK13 →	+0.521	+0.501	<.001	<.001	3	5
UCEC	ABCD2 →	-0.586	-0.343	.007	.008	3	5
HNSC	PPP1R16B →	-0.790	-0.269	<.001	<.001	3	5
HNSC	GIMAP8 →	-0.748	-0.250	<.001	<.001	3	5
OV	CCL19 →	-2.183	-0.361	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,250 associations by consensus.

ITPR3 vs ERGIC1 — BRCA

Explore this scatter interactively →