ITPR3

Across TCGA patient cohorts, ITPR3 mutation is significantly associated with the RNA expression of many other genes, with 8,983 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITPR3-associated genes across cancer lineages are MFAP1, ETFA, and SPATA5L1. Each is linked with ITPR3 in more than 5 cancer types. Because this analysis shows association rather than direction, both ITPR3-to-partner and partner-to-ITPR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MFAP1 grouped by ITPR3-low versus ITPR3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITPR3→partner) and Y-score (partner→ITPR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MFAP1 →	+0.452	+2.110	<.001	<.001	3	6
SKCM	ETFA →	+0.594	+3.472	<.001	.002	3	6
UCEC	SPATA5L1 →	+0.387	+1.172	<.001	<.001	3	6
STAD	COQ3 →	+0.564	+3.523	<.001	<.001	3	6
STAD	NOA1 →	+0.390	+2.452	<.001	.001	3	5
LUAD	WBP11 →	+0.359	+2.611	.007	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,983 associations by consensus.

MFAP1 by ITPR3 expression — COAD

Explore this box plot interactively →