ITPR3

Across TCGA cell cohorts, ITPR3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,821 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ITPR3-associated GO terms across cancer lineages are Rho protein signal transduction, Cerebral cortex radial glia-guided migration, and Telencephalon glial cell migration. Each is linked with ITPR3 in more than 13 cancer types. Because this analysis shows association rather than direction, both ITPR3-to-partner and partner-to-ITPR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rho protein signal transduction grouped by ITPR3-low versus ITPR3-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ITPR3→partner) and Y-score (partner→ITPR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Rho protein signal transduction →	+0.094	+0.934	<.001	.001	3	14
BONE	Cerebral cortex radial glia-guided migration →	+0.147	+1.364	<.001	.001	3	13
BONE	Telencephalon glial cell migration →	+0.147	+1.364	<.001	.001	3	13
UPPER_AERODIGESTIVE_TRACT	Cilium movement →	-0.095	-1.027	<.001	.003	3	12
LUNG_SCLC	Regulation of plasma membrane bounded cell projection assembly →	+0.044	+1.355	<.001	<.001	3	11
LUNG_NSCLC_LUSC	Positive regulation of ruffle assembly →	+0.188	+0.989	.001	<.001	2	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,821 associations by consensus.

Rho protein signal transduction by ITPR3 expression — PANCREAS

Explore this box plot interactively →