ITPR2

Across TCGA patient cohorts, ITPR2 mutation is significantly associated with the RNA expression of many other genes, with 7,128 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITPR2-associated genes across cancer lineages are B3GNT4, PSMD9, and MFN2. Each is linked with ITPR2 in more than 5 cancer types. Because this analysis shows association rather than direction, both ITPR2-to-partner and partner-to-ITPR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, B3GNT4 grouped by ITPR2-low versus ITPR2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITPR2→partner) and Y-score (partner→ITPR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	B3GNT4 →	+0.670	+3.727	<.001	<.001	3	6
COAD	PSMD9 →	+0.359	+2.916	<.001	<.001	3	5
UCEC	MFN2 →	+0.331	+1.502	<.001	<.001	3	5
COAD	SDHB →	+0.440	+2.351	<.001	.003	3	5
UCEC	ZWINT →	+0.493	+1.584	<.001	<.001	3	5
LUAD	AUNIP →	+0.800	+2.249	<.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,128 associations by consensus.

B3GNT4 by ITPR2 expression — COAD

Explore this box plot interactively →