ITPR2

Across TCGA cell cohorts, ITPR2 mutation is significantly associated with the RNA expression of many other genes, with 679 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ITPR2-associated genes across cancer lineages are IYD, FBXO36, and ERO1A. Each is linked with ITPR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ITPR2-to-partner and partner-to-ITPR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IYD grouped by ITPR2-low versus ITPR2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITPR2→partner) and Y-score (partner→ITPR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	IYD →	+0.042	+3.648	.006	.002	3	2
BLOOD_Leukemia	FBXO36 →	+0.541	+3.231	<.001	.007	3	2
BLOOD_Leukemia	ERO1A →	+0.639	+3.199	.004	.007	3	2
BLOOD_Leukemia	HACE1 →	+0.799	+3.199	.006	.007	3	2
CNS	H4C13 →	+0.416	+3.893	<.001	.001	3	2
LARGE_INTESTINE	ARFRP1 →	-0.562	-1.459	.002	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 679 associations by consensus.

IYD by ITPR2 expression — SKIN

Explore this box plot interactively →