ITPR1

Across TCGA patient cohorts, ITPR1 mutation is significantly associated with the total protein of many other genes, with 77 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITPR1-associated genes across cancer lineages are Caspase-7-cleavedD198, TFRC, and 4E-BP1_pT70. Each is linked with ITPR1 in more than 4 cancer types. Because this analysis shows association rather than direction, both ITPR1-to-partner and partner-to-ITPR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ITPR1-low versus ITPR1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITPR1→partner) and Y-score (partner→ITPR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.022	+2.078	<.001	<.001	3	5
SKCM	TFRC →	+0.511	+1.947	.002	<.001	3	4
SKCM	4E-BP1_pT70 →	+0.112	+1.824	.043	.013	3	4
STAD	eIF4E →	+0.173	+3.190	.008	.008	3	3
UCEC	4E-BP1 →	+0.245	+1.893	<.001	<.001	3	3
COAD	eEF2 →	+0.246	+2.807	.007	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 77 associations by consensus.

Caspase-7-cleavedD198 by ITPR1 expression — COAD

Explore this box plot interactively →