ITPR1-DT

Across TCGA pan-cancer cohorts, ITPR1-DT RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated ITPR1-DT data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher ITPR1-DT RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ITPR1-DT expression acts as an unfavorable survival marker, although some lineages such as BLCA and UCS show a favorable association.

KIRC, BLCA, and UCS are the cancer types where ITPR1-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.533	0.710	<.001	123	view →
BLCA	OS	Quartile	All	0.806	0.607	.001	102	view →
UCS	OS	Tertile	III,IV	0.738	0.260	.003	84	view →
LIHC	DFS	Median	All	0.470	0.611	<.001	51	view →
COAD	DFS	Median	All	0.699	0.847	<.001	46	view →
ACC	DFS	Tertile	All	0.373	0.791	<.001	40	view →
CESC	DFS	Tertile	All	0.649	0.829	.001	24	view →
THYM	DFS	Median	II,III,IV	0.872	0.587	.004	24	view →
PAAD	DFS	Quartile	All	0.410	0.202	.010	13	view →
SKCM	DFS	Median	III,IV	0.355	0.684	<.001	10	view →
THCA	OS	Median	IV	0.581	1.000	.007	10	view →
UVM	DFS	Tertile	II,III,IV	0.796	0.489	.036	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

ITPR1-DT–KIRC (DFS)

Open the KIRC breakdown →