ITPKC

Across TCGA patient cohorts, ITPKC protein abundance is significantly associated with the RNA expression of many other genes, with 14,898 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible ITPKC-associated genes across cancer lineages are IRAK1BP1, GJB2, and HTR2A. Each is linked with ITPKC in more than 4 cancer types. Because this analysis shows association rather than direction, both ITPKC-to-partner and partner-to-ITPKC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ITPKC versus IRAK1BP1 in HNSC, with a Pearson correlation of -0.55.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITPKC→partner) and Y-score (partner→ITPKC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	IRAK1BP1 →	-1.040	-0.759	<.001	<.001	3	5
HNSC	GJB2 →	+1.440	+0.422	<.001	<.001	3	5
GBM	HTR2A →	-0.545	-0.252	.006	.005	3	4
PDAC	NISCH →	-0.373	-0.540	<.001	<.001	3	4
HNSC	ATP8A1 →	-0.862	-0.403	.001	<.001	3	4
HNSC	COG2 →	-0.556	-0.534	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,898 associations by consensus.

ITPKC vs IRAK1BP1 — HNSC

Explore this scatter interactively →