ITPKC

Across TCGA patient cohorts, ITPKC mutation is significantly associated with the RNA expression of many other genes, with 1,679 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITPKC-associated genes across cancer lineages are RNU6-660P, MIR6894, and MTCO2P21. Each is linked with ITPKC in more than 2 cancer types. Because this analysis shows association rather than direction, both ITPKC-to-partner and partner-to-ITPKC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-660P grouped by ITPKC-low versus ITPKC-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITPKC→partner) and Y-score (partner→ITPKC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU6-660P →	+0.180	+4.384	<.001	.008	3	3
UCEC	MIR6894 →	+0.487	+2.081	.001	.001	3	2
BRCA	MTCO2P21 →	+0.084	+3.373	.008	.001	3	2
UCEC	LINC01775 →	+0.466	+2.087	<.001	.006	3	2
UCEC	HOMER3-AS1 →	+0.293	+2.979	.003	<.001	3	2
UCEC	RPL23AP82 →	+0.421	+3.708	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,679 associations by consensus.

RNU6-660P by ITPKC expression — CESC

Explore this box plot interactively →