ITPKC

Across TCGA cell cohorts, ITPKC RNA expression is significantly associated with the go_rna of many other GO terms, with 4,692 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ITPKC-associated GO terms across cancer lineages are Negative regulation of autophagy, Positive regulation of endoplasmic reticulum unfolded protein response, and Phospholipid biosynthetic process. Each is linked with ITPKC in more than 15 cancer types. Because this analysis shows association rather than direction, both ITPKC-to-partner and partner-to-ITPKC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of autophagy grouped by ITPKC-low versus ITPKC-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ITPKC→partner) and Y-score (partner→ITPKC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of autophagy →	+0.108	+1.144	<.001	.003	3	16
URINARY_TRACT	Positive regulation of endoplasmic reticulum unfolded protein response →	+0.093	+1.147	.001	<.001	3	16
STOMACH	Phospholipid biosynthetic process →	+0.049	+1.444	.003	.007	3	16
STOMACH	Process utilizing autophagic mechanism →	+0.086	+1.770	.002	<.001	3	16
STOMACH	Autophagy →	+0.086	+1.770	.002	<.001	3	16
LUNG_NSCLC_LUSC	Meiotic chromosome segregation →	-0.165	-1.054	<.001	.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,692 associations by consensus.

Negative regulation of autophagy by ITPKC expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →