ITPKC

Across TCGA cell cohorts, ITPKC mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ITPKC-associated genes across cancer lineages are TFDP3, RXFP2, and OR9K2. Each is linked with ITPKC in more than 2 cancer types. Because this analysis shows association rather than direction, both ITPKC-to-partner and partner-to-ITPKC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFDP3 grouped by ITPKC-low versus ITPKC-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITPKC→partner) and Y-score (partner→ITPKC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TFDP3 →	+0.020	+3.196	.001	.007	3	3
OESOPHAGUS	RXFP2 →	+0.015	+4.857	<.001	<.001	3	1
OESOPHAGUS	OR9K2 →	+0.201	+4.017	<.001	.007	3	1
OESOPHAGUS	GABRR3 →	+0.098	+4.017	<.001	.007	3	1
BLOOD_Lymphoma	NOBOX →	+0.006	+6.247	<.001	<.001	3	1
BLOOD_Lymphoma	CCL7 →	+0.098	+4.867	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

TFDP3 by ITPKC expression — LARGE_INTESTINE

Explore this box plot interactively →