ITPKC

Across TCGA cell cohorts, ITPKC mutation is significantly associated with the mutation status of many other genes, with 2,641 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ITPKC-associated genes across cancer lineages are HTR1B, ATG2A, and CHST15. Each is linked with ITPKC in more than 4 cancer types. Because this analysis shows association rather than direction, both ITPKC-to-partner and partner-to-ITPKC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HTR1B grouped by ITPKC-low versus ITPKC-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITPKC→partner) and Y-score (partner→ITPKC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HTR1B →	+3.781	+5.129	<.001	<.001	1	5
OVARY	ATG2A →	+3.217	+3.684	.006	.006	1	5
LARGE_INTESTINE	CHST15 →	+2.874	+3.632	.002	.002	1	5
OESOPHAGUS	FMN2 →	+4.672	+4.672	.001	.001	1	4
LUNG_NSCLC_LUAD	NPC1L1 →	+3.133	+3.906	.001	.001	1	4
LUNG_NSCLC_LUAD	GLI2 →	+2.396	+3.342	.006	.006	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,641 associations by consensus.

HTR1B by ITPKC expression — LARGE_INTESTINE

Explore this box plot interactively →