ITPKB

Across TCGA pan-cancer cohorts, ITPKB mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of ITPKB’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ITPKB mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types ITPKB is over-expressed in tumor, although a few such as COAD and LUAD show the opposite, repressed pattern.

COAD, LUAD, and LSCC are the cancer types where ITPKB tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ITPKB mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	−1.494	<.001	10	view →
LUAD	Male	II,III,IV	−0.389	<.001	8	view →
LSCC	Female	All	−0.312	<.001	8	view →
CCRCC	Male	III,IV	−0.212	<.001	7	view →
HNSC	Female	All	−0.297	.030	3	view →
OV	All	All	−0.499	.025	2	view →
PDAC	Male	III,IV	−0.425	.018	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

ITPKB–COAD

Open the COAD breakdown →