ITPKA

Across TCGA patient cohorts, ITPKA mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITPKA-associated genes across cancer lineages are FoxM1, Ku80, and Myosin-IIa_pS1943. Each is linked with ITPKA in more than 1 cancer types. Because this analysis shows association rather than direction, both ITPKA-to-partner and partner-to-ITPKA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by ITPKA-low versus ITPKA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITPKA→partner) and Y-score (partner→ITPKA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.413	+2.817	.009	.036	3	1
UCEC	Ku80 →	+0.375	+2.820	.009	.036	3	1
UCEC	Myosin-IIa_pS1943 →	+0.305	+2.820	.015	.036	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

FoxM1 by ITPKA expression — UCEC

Explore this box plot interactively →