ITPA

Across TCGA pan-cancer cohorts, ITPA mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ITPA data layer compared with 23 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ITPA mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ITPA expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

UCEC, HNSC, and PDAC are the cancer types where ITPA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	1.000	0.938	.026	6	view →
HNSC	DFS	Tertile	III,IV	0.763	0.541	.026	5	view →
PDAC	DFS	Tertile	IV	0.217	0.777	.024	4	view →
LSCC	DFS	Tertile	All	0.965	0.900	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ITPA–UCEC (DFS)

Open the UCEC breakdown →