ITPA

Across TCGA pan-cancer cohorts, ITPA mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of ITPA’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where ITPA mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types ITPA is over-expressed in tumor, although a few such as HNSC and PDAC show the opposite, repressed pattern.

CCRCC, LSCC, and LUAD are the cancer types where ITPA tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ITPA mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	III,IV	+0.461	<.001	9	view →
LSCC	Male	All	+0.489	<.001	8	view →
LUAD	Male	II,III,IV	+0.448	<.001	7	view →
COAD	All	All	+0.180	.001	5	view →
OV	All	All	+0.712	.009	2	view →
HNSC	All	IV	−0.221	.008	2	view →
PDAC	Male	IV	−0.225	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

ITPA–CCRCC

Open the CCRCC breakdown →