ITPA

Across TCGA patient cohorts, ITPA RNA expression is significantly associated with the protein abundance of many other proteins, with 10,905 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ITPA-associated proteins across cancer lineages are TRMT6, ESF1, and MAVS. Each is linked with ITPA in more than 7 cancer types. Because this analysis shows association rather than direction, both ITPA-to-partner and partner-to-ITPA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ITPA versus TRMT6 in LSCC, with a Pearson correlation of 0.57.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ITPA→partner) and Y-score (partner→ITPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TRMT6 →	+0.402	+0.528	<.001	<.001	3	8
LSCC	ESF1 →	+0.373	+0.515	<.001	<.001	3	6
COAD	MAVS →	+0.395	+0.639	<.001	<.001	3	5
COAD	ZCCHC3 →	+0.516	+0.765	<.001	<.001	3	5
LSCC	PUS7 →	+0.685	+0.584	<.001	<.001	3	5
LSCC	PCNA →	+0.666	+0.595	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,905 associations by consensus.

ITPA vs TRMT6 — LSCC

Explore this scatter interactively →