ITPA

Across TCGA patient cohorts, ITPA protein abundance is significantly associated with the RNA expression of many other genes, with 5,380 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ITPA-associated genes across cancer lineages are PSMF1, IDH3B, and CXCR1. Each is linked with ITPA in more than 4 cancer types. Because this analysis shows association rather than direction, both ITPA-to-partner and partner-to-ITPA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ITPA versus PSMF1 in COAD, with a Pearson correlation of 0.42.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITPA→partner) and Y-score (partner→ITPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PSMF1 →	+0.610	+0.510	<.001	<.001	3	5
OV	IDH3B →	+0.571	+0.459	<.001	<.001	3	4
PDAC	CXCR1 →	-1.167	-0.408	<.001	<.001	3	4
COAD	SNX5 →	+0.549	+0.411	.003	.004	3	4
COAD	TRMT6 →	+0.594	+0.348	<.001	<.001	3	4
COAD	PTPRA →	+0.620	+0.568	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,380 associations by consensus.

ITPA vs PSMF1 — COAD

Explore this scatter interactively →