ITPA

Across TCGA patient cohorts, ITPA mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITPA-associated genes across cancer lineages are Acetyl-a-Tubulin-Lys40, JNK2, and MEK1. Each is linked with ITPA in more than 1 cancer types. Because this analysis shows association rather than direction, both ITPA-to-partner and partner-to-ITPA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Acetyl-a-Tubulin-Lys40 grouped by ITPA-low versus ITPA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITPA→partner) and Y-score (partner→ITPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.655	+3.000	.025	.037	3	1
UCEC	JNK2 →	+0.296	+3.000	.009	.037	3	1
UCEC	MEK1 →	+0.598	+3.000	.004	.036	3	1
UCEC	PREX1 →	-0.329	-3.000	.038	.037	3	1
UCEC	EGFR_pY1068 →	-0.379	-3.000	.008	.037	2	1
UCEC	INPP4B →	-0.485	-3.000	.009	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Acetyl-a-Tubulin-Lys40 by ITPA expression — UCEC

Explore this box plot interactively →