ITPA

Across TCGA cell cohorts, ITPA RNA expression is significantly associated with the go_rna of many other GO terms, with 2,188 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ITPA-associated GO terms across cancer lineages are Regulation of peroxisome organization, Regulation of mitochondrial mRNA stability, and Positive regulation of protein localization to endoplasmic reticulum. Each is linked with ITPA in more than 11 cancer types. Because this analysis shows association rather than direction, both ITPA-to-partner and partner-to-ITPA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of peroxisome organization grouped by ITPA-low versus ITPA-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ITPA→partner) and Y-score (partner→ITPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Regulation of peroxisome organization →	+0.193	+0.741	.002	.003	2	12
LUNG_SCLC	Regulation of mitochondrial mRNA stability →	+0.143	+0.775	<.001	<.001	3	9
BREAST	Positive regulation of protein localization to endoplasmic reticulum →	+0.079	+1.135	<.001	<.001	3	9
BONE	Mitochondrial tRNA pseudouridine synthesis →	+0.138	+0.690	.001	<.001	3	9
BLOOD_Lymphoma	Mitochondrial large ribosomal subunit assembly →	+0.096	+0.562	<.001	<.001	3	8
URINARY_TRACT	Endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.095	+0.579	.001	<.001	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,188 associations by consensus.

Regulation of peroxisome organization by ITPA expression — URINARY_TRACT

Explore this box plot interactively →