ITM2C

Across TCGA pan-cancer cohorts, ITM2C mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ITM2C data layer compared with 22 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher ITM2C mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ITM2C expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

LSCC, HNSC, and GBM are the cancer types where ITM2C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	II,III,IV	0.519	0.925	<.001	51	view →
HNSC	OS	Tertile	III,IV	0.973	0.798	.003	20	view →
GBM	OS	Tertile	All	0.279	0.501	.009	10	view →
PDAC	DFS	Quartile	II,III,IV	0.219	0.571	.017	9	view →
CCRCC	DFS	Tertile	All	0.953	0.636	.013	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ITM2C–LSCC (OS)

Open the LSCC breakdown →