ITM2BP1

Across TCGA pan-cancer cohorts, ITM2BP1 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of ITM2BP1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ITM2BP1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ITM2BP1 is over-expressed in tumor, although a few such as READ and BRCA show the opposite, repressed pattern.

KIRC, READ, and BRCA are the cancer types where ITM2BP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ITM2BP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	+0.283	<.001	10	view →
READ	All	All	−0.130	.001	5	view →
BRCA	All	III,IV	−0.215	<.001	4	view →
LUSC	All	All	−0.117	.008	4	view →
THCA	All	All	−0.171	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

ITM2BP1–KIRC

Open the KIRC breakdown →