ITM2B

Across TCGA patient cohorts, ITM2B mutation is significantly associated with the RNA expression of many other genes, with 1,110 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITM2B-associated genes across cancer lineages are RPS12P15, RN7SL148P, and RNU7-53P. Each is linked with ITM2B in more than 1 cancer types. Because this analysis shows association rather than direction, both ITM2B-to-partner and partner-to-ITM2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPS12P15 grouped by ITM2B-low versus ITM2B-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITM2B→partner) and Y-score (partner→ITM2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RPS12P15 →	+0.275	+5.693	<.001	.003	3	2
COAD	RN7SL148P →	+0.288	+6.721	.003	<.001	3	2
COAD	RNU7-53P →	+1.479	+6.721	<.001	<.001	3	2
HNSC	RNU6-1037P →	+0.498	+7.954	<.001	.008	3	2
HNSC	MIR668 →	+0.768	+7.954	<.001	.008	3	2
UCEC	RNA5SP412 →	+1.028	+2.967	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,110 associations by consensus.

RPS12P15 by ITM2B expression — COAD

Explore this box plot interactively →