ITM2B

Across TCGA patient cohorts, ITM2B mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITM2B-associated genes across cancer lineages are PCNA, STAT3_pY705, and Bap1-c-4. Each is linked with ITM2B in more than 1 cancer types. Because this analysis shows association rather than direction, both ITM2B-to-partner and partner-to-ITM2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by ITM2B-low versus ITM2B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITM2B→partner) and Y-score (partner→ITM2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.364	+3.000	.001	.036	3	1
UCEC	STAT3_pY705 →	-0.603	-3.321	<.001	.010	3	1
UCEC	Bap1-c-4 →	+0.231	+3.019	.044	.019	3	1
UCEC	INPP4B →	-0.475	-3.308	.005	.010	2	1
UCEC	Caspase-8 →	-0.341	-3.000	.009	.036	2	1
UCEC	4E-BP1 →	+0.536	+3.199	<.001	.009	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

PCNA by ITM2B expression — UCEC

Explore this box plot interactively →