ITM2B

Across TCGA cell cohorts, ITM2B mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ITM2B-associated genes across cancer lineages are DIRAS2, INSM2, and OR9G1. Each is linked with ITM2B in more than 1 cancer types. Because this analysis shows association rather than direction, both ITM2B-to-partner and partner-to-ITM2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DIRAS2 grouped by ITM2B-low versus ITM2B-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITM2B→partner) and Y-score (partner→ITM2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DIRAS2 →	+0.114	+4.087	<.001	.009	3	1
BLOOD_Leukemia	INSM2 →	+0.170	+3.769	.001	.008	3	1
BLOOD_Leukemia	OR9G1 →	+0.213	+3.874	<.001	.005	3	1
BLOOD_Leukemia	OR10T2 →	+0.628	+4.691	<.001	<.001	3	1
BLOOD_Leukemia	FAM24A →	+0.049	+4.384	<.001	.006	3	1
BLOOD_Leukemia	NPY4R →	+0.116	+4.254	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

DIRAS2 by ITM2B expression — BLOOD_Leukemia

Explore this box plot interactively →