ITLN2

Across TCGA patient cohorts, ITLN2 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,046 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible ITLN2-associated GO terms across cancer lineages are Positive regulation of cell cycle G2/M phase transition, Thioester metabolic process, and Regulation of canonical Wnt signaling pathway. Each is linked with ITLN2 in more than 11 cancer types. Because this analysis shows association rather than direction, both ITLN2-to-partner and partner-to-ITLN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of cell cycle G2/M phase transition grouped by ITLN2-low versus ITLN2-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ITLN2→partner) and Y-score (partner→ITLN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Positive regulation of cell cycle G2/M phase transition →	+0.050	+0.610	<.001	<.001	3	12
STAD	Thioester metabolic process →	+0.041	+0.437	<.001	<.001	3	12
STAD	Regulation of canonical Wnt signaling pathway →	+0.060	+0.458	<.001	<.001	3	11
STAD	Acetyl-CoA metabolic process →	+0.049	+0.424	<.001	<.001	3	11
SCLC	Aerobic respiration →	+0.094	+0.880	<.001	<.001	3	11
TGCT	Obsolete positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress →	+0.101	+2.366	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,046 associations by consensus.

Positive regulation of cell cycle G2/M phase transition by ITLN2 expression — STAD

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