ITLN2

Across TCGA patient cohorts, ITLN2 mutation is significantly associated with the RNA expression of many other genes, with 1,670 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITLN2-associated genes across cancer lineages are RNA5SP412, FAM177A1, and SAMD8. Each is linked with ITLN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ITLN2-to-partner and partner-to-ITLN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP412 grouped by ITLN2-low versus ITLN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITLN2→partner) and Y-score (partner→ITLN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP412 →	+0.802	+2.230	<.001	.005	3	2
SKCM	FAM177A1 →	+0.593	+2.591	<.001	.006	3	2
UCEC	SAMD8 →	+0.540	+2.818	.005	.001	3	2
UCEC	PRR14 →	+0.381	+3.346	.005	.005	3	2
UCEC	CPAMD8 →	-1.239	-2.785	.002	.003	3	2
SKCM	DDX11-AS1 →	+0.392	+2.629	.004	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,670 associations by consensus.

RNA5SP412 by ITLN2 expression — UCEC

Explore this box plot interactively →