ITLN2

Across TCGA cell cohorts, ITLN2 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ITLN2-associated genes across cancer lineages are LYZL6, CRNN, and TRPC5OS. Each is linked with ITLN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ITLN2-to-partner and partner-to-ITLN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LYZL6 grouped by ITLN2-low versus ITLN2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITLN2→partner) and Y-score (partner→ITLN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LYZL6 →	+0.029	+4.969	<.001	.003	3	1
SKIN	CRNN →	+0.061	+4.199	<.001	.007	3	1
SKIN	TRPC5OS →	+0.032	+3.938	<.001	.005	3	1
LARGE_INTESTINE	TMEFF2 →	+0.235	+4.013	<.001	.001	3	1
LARGE_INTESTINE	ADAMTS5 →	+0.040	+4.332	<.001	.005	3	1
LARGE_INTESTINE	CLDN17 →	+0.042	+3.345	.005	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

LYZL6 by ITLN2 expression — BLOOD_Leukemia

Explore this box plot interactively →