ITLN2

Across TCGA cell cohorts, ITLN2 mutation is significantly associated with the mutation status of many other genes, with 1,876 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ITLN2-associated genes across cancer lineages are NELL2, HCFC1, and MCF2L. Each is linked with ITLN2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ITLN2-to-partner and partner-to-ITLN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NELL2 grouped by ITLN2-low versus ITLN2-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITLN2→partner) and Y-score (partner→ITLN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	NELL2 →	+5.502	+5.502	.003	.003	1	3
SOFT_TISSUE	HCFC1 →	+5.502	+5.502	.003	.003	1	3
SOFT_TISSUE	MCF2L →	+5.502	+5.502	.003	.003	1	3
SOFT_TISSUE	FAM193B →	+5.502	+5.502	.003	.003	1	3
LARGE_INTESTINE	ZNF423 →	+1.552	+3.495	.005	.005	1	3
LARGE_INTESTINE	TNS3 →	+2.799	+4.635	<.001	<.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,876 associations by consensus.

NELL2 by ITLN2 expression — SOFT_TISSUE

Explore this box plot interactively →