ITLN1

Across TCGA patient cohorts, ITLN1 mutation is significantly associated with the RNA expression of many other genes, with 491 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITLN1-associated genes across cancer lineages are RNA5SP412, SGTA, and GP1BA. Each is linked with ITLN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ITLN1-to-partner and partner-to-ITLN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP412 grouped by ITLN1-low versus ITLN1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITLN1→partner) and Y-score (partner→ITLN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNA5SP412 →	+0.289	+3.993	<.001	.009	3	3
UCEC	SGTA →	+0.576	+3.721	<.001	<.001	3	2
UCEC	GP1BA →	+0.364	+3.370	.006	.004	3	2
UCEC	CIDECP1 →	+0.449	+3.754	<.001	<.001	3	2
UCEC	SUMO2P7 →	+0.304	+2.088	.004	.007	3	2
UCEC	SHLD3 →	+0.454	+2.595	.009	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 491 associations by consensus.

RNA5SP412 by ITLN1 expression — LUSC

Explore this box plot interactively →