ITLN1

Across TCGA patient cohorts, ITLN1 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITLN1-associated genes across cancer lineages are Rab11, Rad50, and Raptor. Each is linked with ITLN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ITLN1-to-partner and partner-to-ITLN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rab11 grouped by ITLN1-low versus ITLN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITLN1→partner) and Y-score (partner→ITLN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rab11 →	-0.182	-3.150	.016	.019	3	1
UCEC	Rad50 →	-0.292	-3.000	.021	.036	3	1
SKCM	Raptor →	-0.238	-3.169	.015	.019	2	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Rab11 by ITLN1 expression — UCEC

Explore this box plot interactively →