ITLN1

Across TCGA cell cohorts, ITLN1 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ITLN1-associated genes across cancer lineages are OR1L6, C2orf80, and TAS2R7. Each is linked with ITLN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ITLN1-to-partner and partner-to-ITLN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L6 grouped by ITLN1-low versus ITLN1-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITLN1→partner) and Y-score (partner→ITLN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	OR1L6 →	+0.020	+5.169	<.001	.004	3	1
BONE	C2orf80 →	+0.126	+5.169	<.001	.004	3	1
BLOOD_Leukemia	TAS2R7 →	+0.032	+4.922	<.001	.009	3	1
LARGE_INTESTINE	CD300H →	+0.033	+4.415	<.001	.007	3	1
BONE	PKD1L3 →	+0.027	+4.754	<.001	.007	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

OR1L6 by ITLN1 expression — BONE

Explore this box plot interactively →