ITK

Across TCGA patient cohorts, ITK RNA expression is significantly associated with the protein abundance of many other proteins, with 19,330 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ITK-associated proteins across cancer lineages are RCSD1, SASH3, and SEPTIN1. Each is linked with ITK in more than 9 cancer types. Because this analysis shows association rather than direction, both ITK-to-partner and partner-to-ITK results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ITK versus RCSD1 in HNSC, with a Pearson correlation of 0.76.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ITK→partner) and Y-score (partner→ITK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RCSD1 →	+0.759	+1.317	<.001	<.001	3	10
HNSC	SASH3 →	+0.627	+1.315	<.001	<.001	3	10
LSCC	SEPTIN1 →	+1.009	+1.360	<.001	<.001	3	10
UCEC	ADA2 →	+0.605	+0.901	<.001	<.001	3	10
OV	CASP1 →	+0.831	+1.100	<.001	<.001	3	10
OV	CD2 →	+1.405	+1.210	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,330 associations by consensus.

ITK vs RCSD1 — HNSC

Explore this scatter interactively →