ITK

Across TCGA patient cohorts, ITK protein abundance is significantly associated with the RNA expression of many other genes, with 11,741 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ITK-associated genes across cancer lineages are SNRPD3, ADNP2, and SLC25A14. Each is linked with ITK in more than 1 cancer types. Because this analysis shows association rather than direction, both ITK-to-partner and partner-to-ITK results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ITK versus SNRPD3 in PDAC, with a Pearson correlation of -0.84.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITK→partner) and Y-score (partner→ITK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SNRPD3 →	-0.909	-0.696	<.001	<.001	3	2
PDAC	ADNP2 →	-0.493	-0.498	.007	.001	3	2
LSCC	SLC25A14 →	-0.405	-0.531	.001	<.001	3	2
PDAC	CUEDC2 →	-0.403	-0.599	<.001	.003	3	2
PDAC	USP46 →	-0.613	-0.606	<.001	.002	3	2
PDAC	GPN3 →	-0.406	-0.498	.005	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,741 associations by consensus.

ITK vs SNRPD3 — PDAC

Explore this scatter interactively →