ITK

Across TCGA patient cohorts, ITK mutation is significantly associated with the RNA expression of many other genes, with 4,429 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITK-associated genes across cancer lineages are MDH1P2, TRGJP2, and NLN. Each is linked with ITK in more than 3 cancer types. Because this analysis shows association rather than direction, both ITK-to-partner and partner-to-ITK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MDH1P2 grouped by ITK-low versus ITK-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITK→partner) and Y-score (partner→ITK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MDH1P2 →	+0.086	+3.207	<.001	.001	3	4
BRCA	TRGJP2 →	+1.287	+3.667	.001	.008	3	3
UCEC	NLN →	+0.507	+2.338	<.001	.003	3	3
UCEC	KMT5AP1 →	+0.162	+1.620	<.001	.004	3	3
UCEC	SDHA →	+0.481	+2.058	.001	<.001	3	3
UCEC	CNOT7P1 →	+0.135	+2.179	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,429 associations by consensus.

MDH1P2 by ITK expression — COAD

Explore this box plot interactively →