ITK

Across TCGA cell cohorts, ITK RNA expression is significantly associated with the go_rna of many other GO terms, with 3,339 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ITK-associated GO terms across cancer lineages are Positive regulation of ATP biosynthetic process, Positive regulation of purine nucleotide biosynthetic process, and Positive regulation of nucleotide biosynthetic process. Each is linked with ITK in more than 6 cancer types. Because this analysis shows association rather than direction, both ITK-to-partner and partner-to-ITK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of ATP biosynthetic process grouped by ITK-low versus ITK-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ITK→partner) and Y-score (partner→ITK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of ATP biosynthetic process →	+0.113	+0.355	.004	.009	3	7
BLOOD_Leukemia	Positive regulation of purine nucleotide biosynthetic process →	+0.049	+1.323	.003	<.001	3	7
BLOOD_Leukemia	Positive regulation of nucleotide biosynthetic process →	+0.049	+1.323	.003	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	Regulation of cell-matrix adhesion →	+0.059	+0.026	<.001	.008	3	6
UPPER_AERODIGESTIVE_TRACT	Regulation of focal adhesion assembly →	+0.075	+0.032	<.001	.001	3	6
UPPER_AERODIGESTIVE_TRACT	Vesicle-mediated transport to the plasma membrane →	+0.052	+0.045	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,339 associations by consensus.

Positive regulation of ATP biosynthetic process by ITK expression — BONE

Explore this box plot interactively →