ITIH4

Across TCGA pan-cancer cohorts, ITIH4 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated ITIH4 data layer compared with 24 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher ITIH4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ITIH4 expression acts as an unfavorable survival marker, although some lineages such as GBM and CCRCC show a favorable association.

COAD, LUAD, and UCEC are the cancer types where ITIH4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.880	1.000	.020	36	view →
LUAD	OS	Median	III,IV	0.334	0.771	.003	19	view →
UCEC	DFS	Quartile	III,IV	0.262	1.000	.013	14	view →
LSCC	DFS	Quartile	II,III,IV	0.750	1.000	.004	12	view →
GBM	DFS	Tertile	All	0.525	0.258	.036	4	view →
CCRCC	DFS	Median	All	0.861	0.650	.021	4	view →
PDAC	OS	Quartile	II,III,IV	0.546	0.940	.011	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

ITIH4–COAD (DFS)

Open the COAD breakdown →