ITIH4

Across TCGA patient cohorts, ITIH4 protein abundance is significantly associated with the RNA expression of many other genes, with 12,699 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ITIH4-associated genes across cancer lineages are IL6, MMP19, and GFPT2. Each is linked with ITIH4 in more than 8 cancer types. Because this analysis shows association rather than direction, both ITIH4-to-partner and partner-to-ITIH4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ITIH4 versus IL6 in LSCC, with a Pearson correlation of 0.48.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITIH4→partner) and Y-score (partner→ITIH4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	IL6 →	+1.865	+0.617	<.001	<.001	3	9
GBM	MMP19 →	+1.244	+0.514	<.001	<.001	3	8
GBM	GFPT2 →	+0.994	+0.459	.002	.008	3	7
GBM	IL10 →	+0.687	+0.614	<.001	<.001	3	7
BRCA	DIPK2B →	+0.705	+0.491	<.001	<.001	3	7
GBM	SOCS3 →	+1.140	+0.499	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,699 associations by consensus.

ITIH4 vs IL6 — LSCC

Explore this scatter interactively →