ITIH4

Across TCGA patient cohorts, ITIH4 mutation is significantly associated with the RNA expression of many other genes, with 3,685 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITIH4-associated genes across cancer lineages are PHF5A, TPI1, and PIMREG. Each is linked with ITIH4 in more than 2 cancer types. Because this analysis shows association rather than direction, both ITIH4-to-partner and partner-to-ITIH4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PHF5A grouped by ITIH4-low versus ITIH4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITIH4→partner) and Y-score (partner→ITIH4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PHF5A →	+0.480	+2.369	<.001	<.001	3	3
UCEC	TPI1 →	+0.411	+2.499	.001	<.001	3	3
UCEC	PIMREG →	+0.733	+2.321	<.001	<.001	3	3
UCEC	NR2C2AP →	+0.321	+1.890	.004	.004	3	3
UCEC	RNA5SP413 →	+0.751	+1.561	<.001	.002	3	3
UCEC	SAC3D1 →	+0.380	+2.102	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,685 associations by consensus.

PHF5A by ITIH4 expression — UCEC

Explore this box plot interactively →