ITIH4

Across TCGA cell cohorts, ITIH4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,321 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ITIH4-associated GO terms across cancer lineages are Mitotic cytokinesis, Negative regulation of syncytium formation by plasma membrane fusion, and Macroautophagy. Each is linked with ITIH4 in more than 12 cancer types. Because this analysis shows association rather than direction, both ITIH4-to-partner and partner-to-ITIH4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitotic cytokinesis grouped by ITIH4-low versus ITIH4-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ITIH4→partner) and Y-score (partner→ITIH4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Mitotic cytokinesis →	+0.065	+0.756	.009	.004	3	13
OESOPHAGUS	Negative regulation of syncytium formation by plasma membrane fusion →	+0.158	+0.891	<.001	<.001	3	13
OESOPHAGUS	Macroautophagy →	+0.057	+0.724	<.001	<.001	3	13
OESOPHAGUS	Negative regulation of myoblast fusion →	+0.159	+0.885	<.001	<.001	3	13
BONE	mRNA catabolic process →	+0.050	+0.873	.003	.001	3	11
LUNG_SCLC	Target-directed miRNA degradation →	+0.114	+0.688	<.001	.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,321 associations by consensus.

Mitotic cytokinesis by ITIH4 expression — URINARY_TRACT

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